The Importance of Plant Extract in Improving the Microflora of the Gastrointestinal Tract in the Treatment of Diseases of the Stomach and Duodenum

Abstract

The paper presents the results of studying the anti-ulcer activity of a combination of complex plant extracts on experimental models of stress and acetylsalicylic gastric ulcers when administered per os extract at a dose of 150 mg/ kg to laboratory animals. The experiments were performed on nonlinear male rats and mongrel male mice. Determination of the Pauls index, the anti–ulcer action index (AUE) - the main criteria for evaluating the anti-ulcer activity of drugs. It is shown that in stress ulcers, the effectiveness of the extract is characterized by a decrease in large, point, stripe-shaped ulcers, a decrease in the number of ulcerative lesions in mice, the AUE index = 4.6. It was found that in the acetylsalicylic model of gastric ulcers against the background of the introduction of the extract, ulcers were detected only in 70% of animals, less pronounced damage to the gastric mucosa was observed, the AUE index is 4.5.